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Leukeran Tablet

Manufactured byGLAXOSMITHKLINE PHARMACEUTICALS LTD
ContainsChlorambucil
CURRENTLY UNAVAILABLE

Description

Leukeran Tablet is an anti-cancer medicine which is used in the treatment of various cancers of the blood. Close monitoring of kidney function and blood cell count are necessary while receiving this medication.
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Side effectsConcernsUsage

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Substitutes

List of substitutes for Leukeran Tablet

Side effects

Major & minor side effects for Leukeran Tablet

Nausea

Vomiting

Diarrhea

Chest pain

Fever and chills

Shortness of breath

Skin Rash

Joint pain

Muscle pain

Black or tarry stools

Uses of Leukeran Tablet

What is it prescribed for?

Hodgkin's Lymphoma

This medicine is used for the treatment of Hodgkin's Lymphoma, a cancer of the lymphatic system that starts from a specific type of white blood cells called lymphocytes marked by the presence of Reed-Sternberg cells.

Chronic Lymphocytic Leukaemia

This medicine is used for the treatment of chronic lymphocytic leukemia which is a cancer of the blood and the bone marrow.

Waldenstrom Macroglobulinemia

This medicine is used for the treatment of Waldenstrom macroglobulinemia, a rare type of blood cancer where the bone marrow produces too many abnormal white blood cells called lymphoplasmacytic cells.

Non-Hodgkin's Lymphoma

This medicine is used in the treatment of non-Hodgkin's lymphoma, a type of cancer that affects certain cells (lymphocytes) of the lymphatic system.
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?

    The amount of time required for this medicine to show its action is not clinically established.

  • How long do the effects of this medicine last?

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Is it safe to consume alcohol while taking this medicine?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is this a habit forming medicine?

    No habit-forming tendencies were reported.

  • Can this medicine be taken during pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Can this medicine be taken while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients who have had demonstrated prior resistance to chlorambucil, or patients with a known allergy to chlorambucil, or any other inactive ingredients present along with this medicine.

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

General warnings

Infections

This medicine should be used with caution due to the increased risk of severe and potentially life-threatening infections. Report any unusual symptoms such as a fever, diarrhea, sore throat, pain or burning during urination, etc. to the doctor immediately. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Seizures

This medicine should be used with caution in patients with seizures or a history of seizures since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Internal bleeding or hemorrhage

This medicine should be used with caution due to the increased risk of internal bleeding or hemorrhages. Any symptoms such as unusual bleeding or bruising, black or tarry stools, vomiting up blood, etc. should be reported to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Bone marrow suppression

This medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Effects on fertility

This medicine may affect the ovarian function and also may cause the absence of monthly menstrual periods in women on therapy. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. If you miss a scheduled dose of this medicine, call your doctor immediately for further instructions.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Live attenuated vaccines and related products

Adalimumab

Azathioprine

Clozapine

Topotecan

Disease interactions

Disease

Information not available.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine on an empty stomach. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.

Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Does not cause sleepiness

How it works

This medicine interferes with DNA synthesis and blocks the growth of cancer cells.

Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Antineoplastics, Alkylating agents

Schedule

Schedule G

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2018 [cited 11 September 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-06866-3&d=201809111016933

[Internet]. Medicines.org.uk. 2018 [cited 11 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.4656.pdf

Chlorambucil - DrugBank [Internet]. Drugbank.ca. 2018 [cited 11 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00291

Related Questions

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Information on this page was last updated on 21 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.