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Ketorolac

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Description

Ketorolac is used in the short-term management of moderate to severe pain. This medicine is not recommended in patients with severe kidney injury. Do not take this medicine if you have any bleeding disorder or have a known allergy to this medicine.
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Side effectsConcernsUsage

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Side effects

Major & minor side effects for Ketorolac

Swelling of face, lips, eyelids, tongue, hands and feet

Unexpected weight gain

Skin rash

Mouth ulcers

Abdominal pain

Decreased urine output

Yellow colored eyes or skin

Diarrhea

Drowsiness

Headache

Pain at the injection site

Uses of Ketorolac

What is it prescribed for?

Moderate to severe pain

Ketorolac is used to relieve moderate to severe pain.
Concerns

Commonly asked questions

  • Onset of action

    The effect of this medicine can be observed in 30 to 60 minutes after an oral dose and 10 minutes after an intramuscular injection.

  • Duration of effect

    The effect of this medicine lasts for an average duration of 4 to 6 hours.

  • Safe with alcohol?

    Alcohol should not be consumed while taking this medicine. Symptoms of stomach bleeding (such as the presence of dried and coffee colored blood in cough or stools) should be reported to the doctor immediately.

  • Is it habit forming?

    No habit forming tendency has been reported.

  • Usage in pregnancy?

    This medicine is not recommended for pregnant women.

  • Usage while breast-feeding?

    This medicine is not recommended in breastfeeding women.

Allergy

Not recommended in patients with known allergy to Ketorolac.

Asthma

Not recommended in patients with a history of NSAID-induced asthma, rhinitis, and urticaria.

Coronary Artery Bypass Surgery (CABG)

Not recommended in patients with recent heart surgery.

Gastro-intestinal bleeding

Not recommended in patients with peptic ulcer disease or any gastrointestinal bleeding disorders.

Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women.

Breast-feeding

This medicine is not recommended in breastfeeding women.

General warnings

Gastro-intestinal bleeding

Ketorolac may cause severe bleeding when taken for a long time. Elderly population with a history of gastrointestinal disease are at a higher risk. Any symptoms of blood in stools and vomiting should be informed to the doctor without delay.

Impaired kidney function

Ketorolac is not recommended in patients with severe kidney injury. Close monitoring of kidney function is necessary. The dose should be adjusted based on the Creatinine clearance.

Impaired liver function

Ketorolac is known to cause liver injury. The baseline of liver enzymes should be obtained before starting the treatment. Inform the doctor if you have any prior history of liver disease. Any symptoms like nausea, vomiting, feeling tired or yellowing of the skin or eyes should be informed to the doctor without delay.

Effect on heart

Ketorolac can have adverse effects on heart, especially after a prolonged duration of use. It could increase the risk of diseases like stroke and heart attack which may be fatal.

Missed Dose

The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost the time for the next dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Drinking alcohol with this medicine substantially increases the risk of stomach bleeding.

Instructions

Alcohol should not be consumed while taking this medicine. Symptoms of stomach bleeding (such as the presence of dried and coffee colored blood in cough or stools) should be reported to the doctor immediately.

Interaction with Medicine

Methotrexate

Warfarin

Corticosteroids

Antihypertensives

Disease interactions

Asthma

Ketorolac should not be taken if you have NSAID-sensitive asthma. Any such history should be reported to the doctor so that an appropriate alternative can be given.

Fluid Retention and edema

Ketorolac should be taken only after consulting a doctor. Monitoring of blood pressure and heart conditions is necessary on a regular basis during the course of therapy.

Skin Rash

Ketorolac may cause potentially fatal skin allergies without any warning. Signs and symptoms like rashes, hives, fever or other allergic symptoms should be reported without any delay. These conditions require immediate medical intervention.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Ketorolac should be taken following all labeled instructions. The duration and amount of medicine consumed should be as prescribed by the doctor. Close monitoring of kidney function is necessary during the treatment. Drink adequate amount of water to minimize the irritation caused in the stomach.

Miscelleneous

To be taken after food

To be taken as instructed by doctor

Does not cause sleepiness

How it works

Ketorolac works by reducing the formation of chemical substances in the body that cause pain and swelling.

Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Nonsteroidal anti-inflammatory agents

Schedule

Schedule H

[Internet]. 2017 [cited 9 June 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/108

DailyMed - Ketorolac tromethamine injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 9 June 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=16399285-31cf-4ae2-b28e-76abf961e6e1

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 9 June 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 9 June 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~8Luo9N:1
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Information on this page was last updated on 5 Jan 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.