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Hydroflumethiazide
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Description
Hydroflumethiazide is a diuretic, also known as a water pill. It is used in combination with other medicines to treat high blood pressure and oedema (swelling due to excess water accumulation in your body tissues). It works by increasing the loss of water from your body through increased urination.
Hydroflumethiazide may cause common side effects such as low blood pressure, high blood sugar levels, dizziness, nausea, vomiting, stomach cramps, diarrhoea, etc. Consult your doctor if these symptoms persist or if they become severe.
Hydroflumethiazide should be taken exactly as advised by your doctor. Take it at the same time every day in order to maintain a constant level of this medicine in your body.
Hydroflumethiazide should be avoided if you are allergic to it. Inform your doctor if you have diabetes, liver or kidney problems before taking this medicine. Close evaluation with respect to your current medicines is necessary to avoid any undesired side effects. If you are pregnant, breastfeeding, or planning a pregnancy, consult your doctor before taking this medication.
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Side effects
Major & minor side effects for Hydroflumethiazide
Low blood pressure
Increased blood sugar levels
Increased sensitivity of the skin to sunlight
Nausea and Vomiting
Diarrhoea
Stomach cramps
Dizziness
Fatigue
Weight gain
Redness of eye
Uses of Hydroflumethiazide
What is it prescribed for?
Hypertension
Hypertension, also known as high blood pressure, is a condition in which your blood pressure is consistently higher than normal. High blood pressure often has no symptoms, but if left untreated it may increase your risk of heart problems and stroke (decreased blood flow to your brain). Hydroflumethiazide is used in combination with other antihypertensive medicines to treat hypertension.
Oedema
Oedema, also known as fluid/water retention is a condition in which there is excess fluid accumulation in your body tissues. This results in pain and swelling of the affected body parts (hands, feet, ankles, etc). Hydroflumethiazide is used in combination with other diuretic medicines (medicines that promote diuresis, which is loss of water through urine) to treat oedema.
Concerns
Commonly asked questions
Onset of action
The time taken by Hydroflumethiazide to show its action is 3-4 hours.Duration of effect
The duration for which Hydroflumethiazide remains active in your body is 2-3 days.Safe with alcohol?
Consumption of alcohol is not recommended when on treatment with Hydroflumethiazide due to the increased risk of low blood pressure. Inform your doctor if you experience any symptoms of headache, dizziness, lightheadedness, fainting, changes in your pulse or heart rate.Is it habit forming?
No habit-forming tendency has been reported with Hydroflumethiazide.Usage in pregnancy?
Hydroflumethiazide is not recommended during pregnancy unless absolutely necessary. If you are pregnant, consult your doctor.Usage while breast-feeding?
It is not known if Hydroflumethiazide passes into breastmilk. If you are breastfeeding, consult your doctor.
Allergy
Avoid taking Hydroflumethiazide if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.
Anuria
Anuria is a condition in which your kidneys are unable to produce urine due to a loss of kidney function. Since Hydroflumethiazide works by increasing your urine output, the effectiveness of this medicine is reduced if you have anuria. Hence this medicine is not recommended if you have this condition.
Warnings for special population
Pregnancy
Hydroflumethiazide is not recommended during pregnancy unless absolutely necessary. If you are pregnant, consult your doctor.
Breast-feeding
It is not known if Hydroflumethiazide passes into breastmilk. If you are breastfeeding, consult your doctor.
General warnings
Other Medicines
Hydroflumethiazide may interact with other medicines and may cause undesired side effects. Inform your doctor about all your current medicines including any herbs or supplements before taking this medicine.
Driving or Operating machines
Hydroflumethiazide may cause dizziness and low blood pressure. Do not drive or operate machines if you experience any symptoms that may affect your mental alertness.
Photosensitivity
Hydroflumethiazide may make your skin more sensitive to sunlight. Avoid excessive exposure to sunlight. Use sunscreen with a high sun protection factor and wear protective clothing.
Missed Dose
Try not to skip a dose of Hydroflumethiazide. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not double the dose to compensate for a missed one.
Overdose
Do not take more dose than that is prescribed by your doctor. Contact your doctor in case of an overdose with Hydroflumethiazide.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended when on treatment with Hydroflumethiazide due to the increased risk of low blood pressure. Inform your doctor if you experience any symptoms of headache, dizziness, lightheadedness, fainting, changes in your pulse or heart rate.
Interaction with Medicine
Olanzapine
Antidiabetic medicines
Levodopa
Alprazolam
Laxatives
Amphotericin B
Hydroxyzine
Amitriptyline
Disease interactions
Electrolyte abnormalities
Hydroflumethiazide is commonly associated with loss of electrolytes (potassium, sodium, chloride, bicarbonate, magnesium), which may increase your risk of arrhythmia (irregular heartbeat) and heart attack. Inform your doctor if you experience any signs and symptoms of fluid or electrolyte imbalance such as dryness in your mouth, thirst, weakness, drowsiness, restlessness, muscle cramps, low blood pressure, decreased urine output, irregular heartbeat, nausea, vomiting, etc. Your fluid and electrolyte abnormalities will be corrected before beginning treatment, and blood pressure will be monitored periodically.
Severe liver disease
Hydroflumethiazide should be used with caution if you have any pre-existing liver problems due to an increased risk of liver damage. Inform your doctor if you experience tremors (involuntary shaking movement in one or more parts of your body), confusion, jaundice (yellowing of your skin or the white part of your eyes).
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus is a condition in which your body's immune system attacks your own tissues and organs. Symptoms may include skin rash, fever, fatigue, joint pain, etc. Hydroflumethiazide should be used with caution if you have this condition as it may worsen your symptoms.
Kidney Disease
Hydroflumethiazide should be used with caution if you have pre-existing kidney problems due to its reduced effectiveness. Since this medicine is eliminated by kidneys it may also increase your risk of severe side effects, resulting from the accumulation of this medicine in your body. Your kidney function will be closely monitored and the dose may be adjusted based on your clinical condition.
Diabetes
Hydroflumethiazide should be used with caution if you have diabetes due to the increased risk of hyperglycaemia (high blood sugar levels) and glycosuria (presence of glucose/sugar in the urine). Your blood sugar levels will be closely monitored and the dose of your anti-diabetic medicines may be adjusted based on your clinical condition.
Hyperlipidaemia
Hyperlipidaemia is a condition with high blood lipid (cholesterol/fat) levels. Hydroflumethiazide may further increase your blood cholesterol levels and should be used with caution if you have a pre-existing history of this condition. Your blood cholesterol levels will be closely monitored and the dose of your medicines may be adjusted based on your clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Hydroflumethiazide with or without food. Do not take more or less than the prescribed dose. Do not stop the use of this medicine without consulting your doctor as it may worsen your condition.
Hydroflumethiazide may cause an imbalance of electrolytes in your body. Periodic monitoring of your electrolyte levels is recommended.
Hydroflumethiazide may increase your blood sugar levels and/or lower your blood pressure. It is recommended to regularly monitor your blood sugar levels and blood pressure.
Avoid alcohol consumption while on treatment with Hydroflumethiazide as it may affect your blood pressure.
Do not drive or operate machines if you experience any symptoms that may affect your alertness after taking Hydroflumethiazide.
Miscelleneous
How it works
Hydroflumethiazide is an oral diuretic. It inhibits the reabsorption of sodium and chloride in the kidneys and promotes loss of water from the body. This helps to treat hypertension and oedema (swelling due to excess water accumulation in your body tissues).
Legal Status
Classification
Category
Diuretics, Thiazide diuretics
Schedule
Schedule H
Pubchem.ncbi.nlm.nih.gov. 2021. Hydroflumethiazide. [online] Available at: < [Accessed 24 September 2021].
Medindia. 2021. Hydroflumethiazide Drug Information - Indications, Dosage, Side Effects and Precautions. [online] Available at: < [Accessed 24 September 2021].
Information on this page was last updated on 26 Oct 2021
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.