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Difluprednate
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Description
Difluprednate is a topical corticosteroid used for the treatment of inflammation and pain associated with eye surgeries. It is also used for the treatment of inflammation of the middle layer of the eye, uvea (uveitis).
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Side effects
Major & minor side effects for Difluprednate
Blurred vision
Decreased vision
Eye discomfort
Eye pain
Redness of the eye
Watery eyes
Dry eyes
Eye irritation
Headache
Uses of Difluprednate
What is it prescribed for?
Postoperative ocular inflammation
This medicine is used for the treatment of inflammation and pain associated with eye surgeries.
Uveitis
This medicine is used for the treatment of endogenous anterior uveitis, an inflammation of the middle layer of the eye, uvea.
Concerns
Commonly asked questions
Onset of action
The amount of time required for this medicine to show its action is not clinically established.Duration of effect
The amount of time for which this medicine remains active in the body is not clinically established.Safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is it habit forming?
No habit-forming tendencies were reported.Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition. If the medicine is used, monitor the infant closely for any adverse effects.
Allergy
This medicine is not recommended for use in patients with a known allergy to difluprednate or any other inactive ingredients present along with it.
Active viral diseases
This medicine is not recommended for use in patients with active viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella due to the increased risk of worsening of the patient's condition.
Mycobacterial or fungal infection
This medicine is not recommended for use in patients with a mycobacterial or fungal infection of the eyes and surrounding structures due to the increased risk of worsening of the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition. If the medicine is used, monitor the infant closely for any adverse effects.
General warnings
Sterility of dropper tip
It is advised that you do not touch the dropper tip to any surface since this may contaminate the contents. Contamination of the medicine may increase the risk of infections.
Intraocular pressure (IOP) Increase
This medicine should be used with extreme caution in patients with a history of cataracts, glaucoma, or increased intraocular pressure due to the increased risk of worsening of the patient's condition. This risk is especially high if the medicine is used for more than 10 days. Close monitoring of intraocular pressure may be necessary in some cases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Slow or delayed healing
This medicine may slow or delay healing and increase the risk of a bleb formation. This risk is especially high if the medicine is used for a prolonged period of time. Appropriate examination through lamp biomicroscopy or fluorescein staining may be necessary in some cases to ensure appropriate healing post surgery. Replacement with a suitable alternative may be required based on the clinical condition.
Contact lens
This medicine is not recommended for use if you are wearing soft contact lenses in your eyes. The lens should be removed prior to administration of the eye drops and can be reinserted 10 to 15 minutes post administration.
Driving or operating machines
This medicine may cause blurred vision or other vision changes in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Missed Dose
Administer the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Smallpox vaccine
Disease interactions
Disease
Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Use this medicine exactly as prescribed. Do not administer in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
This medicine works by reducing the formation of certain substances in the body that are responsible for causing swelling and pain.
Legal Status
Classification
Category
Ophthalmic steroids
Schedule
Schedule H
Difluprednate Ophthalmic: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 23 March 2018]. Available from:
DailyMed - Durezol emulsion [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 23 March 2018]. Available from:
Difluprednate - DrugBank [Internet]. Drugbank.ca. 2018 [cited 23 March 2018]. Available from:
[Internet]. Davisplus.fadavis.com. 2018 [cited 23 March 2018]. Available from:
[Internet]. Pro.durezol.com. 2018 [cited 23 March 2018]. Available from:
[Internet]. Accessdata.fda.gov. 2018 [cited 23 March 2018]. Available from:
[Internet]. Ask.novartispharma.ca. 2018 [cited 23 March 2018]. Available from:
Information on this page was last updated on 3 Apr 2018
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.