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Clavam 375 Tablet
Manufactured byAlkem Laboratories Ltd.
ContainsAmoxycillin (250 mg) + Clavulanic Acid (125 mg)
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Description
Clavam 375 Tablet is an antibiotic combination of Amoxycillin and Clavulanic acid. It is used to treat infections caused by bacteria. Amoxycillin interferes with the growth and division process of the bacterial cell wall while Clavulanic acid enhances the activity of Amoxycillin in treating infections caused by susceptible bacteria.
Clavam 375 Tablet has some side effects like nausea, vomiting, stomach pain, diarrhoea, and skin rash. Consult your doctor at the earliest if any of these effects persist for a long time or worsen. Inform your doctor if you are allergic to this medicine or any other antibiotics.
Clavam 375 Tablet can be taken with food as it improves absorption and decreases the risk of an upset stomach. Make sure you complete the course of treatment even if you feel better after taking a few doses of this medicine. Stopping the use of this medicine early may make the infection come back and harder to treat.
Clavam 375 Tablet is not recommended if you have problems like cholestasis (a condition where the normal flow of bile from the liver is interrupted) and other liver problems. This medicine may cause dizziness and sleepiness. Avoid driving vehicles or operating machines if you feel dizzy or sleepy.
Clavam 375 Tablet can make birth control pills less effective. You may be advised to follow different ways of birth control methods to prevent unwanted pregnancy.
Clavam 375 Tablet is safer for you if you can share your entire medical history with your doctor. This includes any previous episode of allergy, heart problem, a blood disorder, lung problem, stomach or intestinal problem, skin disorder, liver or kidney problems. Inform your doctor if you take any medicine. Inform your doctor if you are pregnant, planning a pregnancy or are breastfeeding.
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Substitutes
List of substitutes for Clavam 375 Tablet
Side effects
Major & minor side effects for Clavam 375 Tablet
Allergic Skin Reaction
Diarrhoea
Joint pain
Skin yellowing
Easy bruising and bleeding
Heavy menstrual bleeding
Tooth discoloration
Nausea or vomiting
Altered sense of taste
Convulsions
Painful intercourse
Swelling of face, lips, eyelids, tongue, hands and feet
Black or tarry stools
Muscle or joint pain
Sleeplessness
Irregular heartbeat
Uses of Clavam 375 Tablet
What is it prescribed for?
Ear infection
Clavam 375 Tablet is used to treat bacterial infections of the middle ear like otitis media (infection and swelling of your middle ear).
Sinusitis
Clavam 375 Tablet is used in the treatment of bacterial infections of the nose and nasal chamber like sinusitis. Sinusitis is an infection and swelling of the lining of the sinuses. Sinuses are hollow spaces in the bones around your nose that connect to the nose through small, narrow channels.
Pharyngitis/Tonsilitis
Pharyngitis and tonsillitis are infections that cause swelling and soreness in your throat and tonsils. Clavam 375 Tablet is used to treat pharyngitis, tonsillitis, and/or pharyngotonsillitis (when both, the throat and tonsils are infected).
Skin and Soft tissue infections
Skin and soft tissue infections occur when the bacteria invade your skin and its supporting structures. Clavam 375 Tablet is used to treat all skin infections caused by bacteria.
Urinary Tract Infection
An infection in any part of your urinary system (kidneys, bladder, ureters, or urethra) is called a urinary tract infection (UTI). UTIs are caused by bacteria and in some cases, viruses or fungi. Clavam 375 Tablet is used to treat urinary tract infections caused by bacteria.
Lower Respiratory Tract Infection
Clavam 375 Tablet is used to treat Pneumonia and Bronchitis
Pneumonia is an infection of the air sacs in your lungs (either single or both lungs). It can be bacterial and viral. This medicine is used to treat pneumonia caused by bacteria.
Bronchitis is the swelling and irritation of bronchial tubes that regulate air passage in your lungs. Clavam 375 Tablet is used to treat bronchitis caused by bacteria.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The effect of Clavam 375 Tablet can be observed within 1-2 hours after taking it.How long do the effects of this medicine last?
The effect of Clavam 375 Tablet lasts for an average duration of 6-8 hours.Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is this a habit forming medicine?
Clavam 375 Tablet has no habit forming tendency.Can this medicine be taken during pregnancy?
Clavam 375 Tablet is advisable in pregnancy only if clearly needed. Your doctor may prescribe this medicine if the benefits outweigh the risks.Can this medicine be taken while breast-feeding?
Clavam 375 Tablet pass into the breastmilk in low levels that are not expected to cause any harmful effects in infants. However, consult your doctor before taking this medicine.
Allergy
It is recommended to avoid taking Clavam 375 Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms like skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.
Cholestasis
Avoid taking Clavam 375 Tablet if you have cholestasis (a condition where the normal flow of bile from your liver is interrupted).
Liver disease
Avoid taking Clavam 375 Tablet if you have a history of liver problems associated with the use of this medicine or any other antibiotics.
Warnings for special population
Pregnancy
Clavam 375 Tablet is advisable in pregnancy only if clearly needed. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast-feeding
Clavam 375 Tablet pass into the breastmilk in low levels that are not expected to cause any harmful effects in infants. However, consult your doctor before taking this medicine.
General warnings
Allergic Reaction
Clavam 375 Tablet is likely to cause moderate to a severe allergic reaction and the likelihood is very high in patients who are known to have an antibiotic allergy. Report to your doctor on priority if you notice any allergic reactions.
Diarrhea
Clavam 375 Tablet can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe diarrhoea that is watery or bloody.
Drug-resistance
Usage of Clavam 375 Tablet without sufficient proof or suspicion of a bacterial infection should be avoided. It may also increase the risk of the development of bacteria that are antibiotic-resistant.
Liver disease
Regular monitoring of the liver enzyme levels is necessary while taking Clavam 375 Tablet and even after completing treatment with this medicine.
Use in children
Clavam 375 Tablet should not be used in children below 12 years of age.
Driving or operating machine
Clavam 375 Tablet may cause dizziness and sleepiness in some patients. Avoid driving vehicles or operating machines if you feel dizzy or sleepy.
Missed Dose
If you missed a Clavam 375 Tablet dose, make sure that you remember to take your next dose on time. Do not take two doses together to make up for a forgotten dose.
Overdose
Never take Clavam 375 Tablet more than the prescribed dose. If you suspect that you might have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Doxycycline
Methotrexate
Warfarin
Ethinyl Estradiol
Live vaccines
Disease interactions
Mononucleosis
People with mononucleosis (kissing disease- transmitted by saliva) may develop a maculopapular skin rash (a flat red area that is covered with small bumps) after 5-10 days of treatment with this medicine. This resolves within days of discontinuing the use. Clavam 375 Tablet may not be an appropriate medicine in people with mononucleosis.
Colitis
Clavam 375 Tablet can kill the helpful bacteria in your stomach or intestine and leads to diarrhoea. Therefore, use this medicine with extreme caution if you have colitis (swelling of your colon's inner lining).
Kidney diseases
People with kidney diseases need special consideration while taking Clavam 375 Tablet due to the risk of kidney damage. Dose adjustment should be done based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Urine Sugar Test (Benedict's of Fehling's reagent)
Report the use of Clavam 375 Tablet prior to the test. This medicine may give a false-positive result for the presence of glucose/sugar in your urine. The urine sugar test should be performed with a different reagent in case you are taking this medicine.
Take Clavam 375 Tablet with food to avoid an upset stomach.
Finish the prescribed course of Clavam 375 Tablet even if you start to feel better after a few doses. Stopping it early may lead to a recurrence which may be harder to treat.
Diarrhoea may occur as a side effect. Taking probiotics along with Clavam 375 Tablet may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
Stop taking Clavam 375 Tablet and inform your doctor immediately if you develop an itchy rash, swelling of your face, throat or tongue or breathing difficulties while taking it.
Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.
Do not crush, break or chew the tablet in your mouth.
Miscelleneous
How it works
Clavam 375 Tablet is an antibiotic containing Amoxicillin and Clavulanic acid.
Amoxycillin binds to certain specific receptors and prevents the formation of a necessary component for the cell wall building process.
Clavulanic acid is effective against a specific species of bacteria that are resistant to other antibiotic medicines.
Legal Status
Classification
Category
Beta-lactamase inhibitors, Aminopenicillins
Schedule
Schedule H
Pubchem.ncbi.nlm.nih.gov. 2021. Clavulanic acid. [online] Available at: < [Accessed 20 May 2021].
Pubchem.ncbi.nlm.nih.gov. 2021. Amoxicillin. [online] Available at: < [Accessed 22 January 2021].
Drugs, H., 2021. Amoxicillin and Clavulanic Acid: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 20 May 2021].
Dailymed.nlm.nih.gov. 2021. DailyMed - AMOXICILLAN AND CLAVULANATE POTASSIUM tablet, film coated. [online] Available at: < [Accessed 20 May 2021].
Medicines.org.uk. 2021. Co-amoxiclav 250 mg/125 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 27 August 2021].
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Information on this page was last updated on 20 Oct 2021
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.
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