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Ciplar-H (25/40 mg) Tablet
Manufactured byCipla Ltd.
ContainsHydrochlorothiazide (25 mg) + Propranolol (40 mg)
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Description
Ciplar-H (25/40 mg) Tablet is a combination medicine used for the treatment of high blood pressure. Frequent monitoring of blood pressure and electrolytes level is necessary during treatment with this medicine.
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Substitutes
List of substitutes for Ciplar-H (25/40 mg) Tablet
Side effects
Major & minor side effects for Ciplar-H (25/40 mg) Tablet
Increased urination
Itching or rash
Abdominal and stomach pain
Dry mouth
Joint pain, stiffness, and swelling
Cramping
Weakness
Dizziness
Diarrhea
Difficulty in breathing
Skin blistering
Swelling of face, lips, eyelids, tongue, hands and feet
Irregular heartbeat
Weight gain
Hypotension
Chest pain and discomfort
Uses of Ciplar-H (25/40 mg) Tablet
What is it prescribed for?
Hypertension
This medicine is used in the treatment of high blood pressure which may be caused by genetic or environmental factors.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The effect of this medicine can be observed within 1 hour of administration of the dose.How long do the effects of this medicine last?
The effect of this medicine lasts for an average duration of 12 hours.Is it safe to consume alcohol while taking this medicine?
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.Is this a habit forming medicine?
No habit-forming tendencies were reported.Can this medicine be taken during pregnancy?
This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.Can this medicine be taken while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to hydrochlorothiazide, other sulfonamides, propranolol, or any other inactive ingredients present along with these medicines.
Anuria
This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.
Heart Failure
This medicine is not recommended for use in patients with severe heart failure due to the increased risk of worsening of the patient's condition.
Heart rhythm disorders
This medicine is not recommended for use in patients with heart rhythm disorders due to the increased risk of worsening of the patient's condition.
Asthma
This medicine is not recommended for use in patients with asthma or other obstructive diseases of the lung since it may worsen the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings
Hepatic dysfunction
This medicine should be used with extreme caution in patients suffering from liver diseases due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Volume and electrolyte depletion
This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Renal diseases
This medicine may cause Azotemia in patients with a known history of severe renal diseases. Close monitoring of kidney function is necessary while taking this medicine. Replacement with a suitable alternative may be required based on the clinical condition.
Allergy
This medicine should be used with caution in patients with seasonal allergies or allergies to specific food substances since it may increase the severity and frequency of the allergies. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.
Diabetes
This medicine should be administered with extreme caution in patients suffering from diabetes due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Hyperthyroidism
This medicine should be administered with caution in patients suffering from hyperthyroidism since it may mask some of the patient's symptoms. Report any unusual symptoms to the doctor immediately. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Do not stop the use of this medicine without consulting your doctor.
Sports
Athletes are advised not to indulge in certain sports while using this medicine. Archery, racing, shooting and other high-risk sports should be avoided. Sportspersons should refer to the list of medicines published by World Anti-Doping Agency (WADA) which are not to be taken while participating in specific sports events.
Pediatric use
This medicine is not recommended for use in children and adolescents since the safety and efficacy of use are not clinically established.
Missed Dose
The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine
Amlodipine
Diltiazem
Lidocaine
Insulin
Aminophylline
Formoterol
Epinephrine
Antidepressants
Nonsteroidal anti-inflammatory medicines
Disease interactions
Hyperuricemia
This medicine should be used with caution in patients with a history of gout or chronic renal failure due to the increased risk of hyperuricemia. Close monitoring of uric acid level is recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Asthma
This medicine is not recommended for use in patients with bronchial asthma or chronic obstructive pulmonary disease since it may worsen the patient's condition. Replacement with a suitable alternative should be done under your doctor's supervision.
Heart Disease
This medicine is not recommended for use in patients with heart diseases since it may worsen the patient's condition. Replacement with a suitable alternative should be done under your doctor's supervision.
Diabetes
This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Coadministration of multivitamin with minerals and this combination medicine should be avoided since it may decrease the effects of the medicine. A time gap of at least 2 hours should be maintained between the administration of multivitamin with minerals and this combination medicine to avoid their interaction.
Lab interactions
Information not available.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. It is advised to take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
Hydrochlorothiazide increases the excretion of water and sodium through the urine. Propranolol relaxes the blood vessels and reduces the heart rate, promoting a smooth flow of the blood. Their combination is thus effective in reducing the blood pressure.
Legal Status
Classification
Category
Antihypertensive combinations, Beta blockers with thiazides
Schedule
Schedule H
DailyMed - Propranolol hydrochloride capsule, extended release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 15 March 2017]. Available from:
DailyMed - Hydrochlorothiazide tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 28 July 2017]. Available from:
[Internet]. 2017 [cited 27 September 2017]. Available from:
Propranolol Hydrochloride and Hydrochlorothiazide (hydrochlorothiazide/propranolol hydrochloride) dose, indications, adverse effects, interactions... from PDR.net [Internet]. Pdr.net. 2017 [cited 27 September 2017]. Available from:
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Information on this page was last updated on 10 Oct 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.