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Certican 0.25 Tablet

Manufactured byNOVARTIS INDIA LTD
ContainsEverolimus
CURRENTLY UNAVAILABLE

Description

Certican 0.25 Tablet is an immunosuppressant medicine that contains Everolimus. It is used to prevent your immune system from rejecting an organ that has been transplanted via surgery (eg. kidney and liver transplants). It may also be used in combination with other medicines to treat certain types of cancers of the breasts, kidneys, pancreas, intestines, lungs, brain, etc. Certican 0.25 Tablet can cause side effects like infections, sinusitis, cough, fever, fatigue, swelling of the mouth, infection of the throat, infection of the ear, and diarrhoea. Inform your doctor if any of these symptoms persist for a long time. Seek medical help if you notice any increase in thirst and frequency of urination or if you have difficulty in breathing. Avoid taking Certican 0.25 Tablet if you have a cough or fever, or need to receive any vaccination as it decreases the immune system's ability of your body to fight infection. Certican 0.25 Tablet is not recommended for use if you are pregnant, planning pregnancy or breastfeeding. Consult your doctor before using this medicine. Certican 0.25 Tablet is not recommended if you have severe liver problems. Inform your doctor if you are using any other medicines for underlying health conditions. Certican 0.25 Tablet can cause fatigue so it is advisable to not do any activity that requires your concentration like driving vehicles or operating machines. Avoid drinking grapefruit juice while using Certican 0.25 Tablet as a chemical in the juice can interfere with the action and reduce its therapeutic benefits.
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Substitutes

List of substitutes for Certican 0.25 Tablet

Lanolimus 0.25 Tablet
Mylan Pharmaceuticals

Side effects

Major & minor side effects for Certican 0.25 Tablet

Swelling of the face, arms, hands, lower legs, or feet

Chest pain

Chills and fever

Diarrhoea

Difficulty in swallowing

Difficult or painful urination

Rapid weight gain

Tingling of hands or feet

Bleeding gums

Blurred vision

Nausea and vomiting

Slow heart rate

Sweating

Unusual tiredness or weakness

Dry skin

Headache

Hair loss

Missed or irregular menstrual periods

Cough

Irregular breathing

Uses of Certican 0.25 Tablet

What is it prescribed for?

Organ transplant - rejection prophylaxis

Transplant rejection occurs when transplanted tissue is rejected by your own immune system, which destroys the transplanted tissue. Certican 0.25 Tablet is used to prevent the rejection of organ transplants like kidney, liver, heart etc.

Advanced breast cancer

Certican 0.25 Tablet is used in postmenopausal women when other medicines have failed to show significant improvement. It helps to stop cancer growth and further spread and relieves the symptoms of breast cancer such as breast lumps, bloody discharge from the nipple etc. Take this medicine as advised by your doctor to get maximum benefits.

Advanced kidney cancer

Certican 0.25 Tablet is used in the treatment of kidney cancer after the failure of treatment with other first-line medicines. It stops the growth and multiplication of cancer cells. Take this medicine as advised by your doctor to get maximum benefits.

Pancreatic cancer

Pancreatic cancer develops when uncontrolled cell growth begins in a part of your pancreas. Symptoms include jaundice and abdominal pain, but these might not appear until the later stages. Certican 0.25 Tablet is used in the treatment of progressive neuroendocrine tumours of the pancreas by stopping the growth and multiplication of cancer cells. Take this medicine as advised by your doctor to get maximum benefits.

Advanced neuroendocrine cancer

Neuroendocrine cancers are cancers that begin in specialized cells called neuroendocrine cells. Neuroendocrine cells have traits similar to those of nerve cells and hormone-producing cells. Neuroendocrine cancers are rare and can occur anywhere in your body. Certican 0.25 Tablet is used in the treatment of neuroendocrine cancers of the pancreas, gastrointestinal tract, or lung origin.

Brain/Intracranial tumour

A brain tumour is a mass or growth of abnormal cells in your brain. Many different types of brain tumours exist. Some brain tumours are noncancerous. Certican 0.25 Tablet is used in the treatment of brain tumours associated with a rare genetic condition.

Tuberous sclerosis complex (TSC)-associated partial-onset seizures

Certican 0.25 Tablet is used along with other medicines for the treatment of TSC-associated partial-onset seizures in adults and children older than two years.
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?

    The amount of time required for Certican 0.25 Tablet to show its effect is 1-2 hours after taking it.

  • How long do the effects of this medicine last?

    The amount of time for which Certican 0.25 Tablet remains active in the body is not known.

  • Is it safe to consume alcohol while taking this medicine?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is this a habit forming medicine?

    No habit-forming tendencies were reported for Certican 0.25 Tablet.

  • Can this medicine be taken during pregnancy?

    Certican 0.25 Tablet is not recommended for use in pregnancy unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

  • Can this medicine be taken while breast-feeding?

    Certican 0.25 Tablet is not recommended for use in breastfeeding unless absolutely necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

Avoid taking Certican 0.25 Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Warnings for special population

Pregnancy

Certican 0.25 Tablet is not recommended for use in pregnancy unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

Certican 0.25 Tablet is not recommended for use in breastfeeding unless absolutely necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

General warnings

Vaccination

The administration of live vaccines is not recommended during treatment with Certican 0.25 Tablet due to the increased risk of serious side effects. It is advised to avoid contact with individuals who have received live vaccines. You are also recommended to be up to date with all required immunizations before initiating therapy with this medicine.

Blood sugar levels

Certican 0.25 Tablet may increase blood sugar levels. Monitoring of fasting blood sugar levels is recommended before starting the treatment with this medicine and periodically thereafter.

Cholesterol levels

Certican 0.25 Tablet may increase cholesterol and triglyceride levels. Monitoring of fasting lipid profile is recommended before starting therapy with this medicine and periodically thereafter.

Wound healing and fluid accumulation

Certican 0.25 Tablet may delay wound healing and increase the risk of wound-related complications which may require surgical intervention. It also may cause fluid accumulation, including swelling of feet, other types of localized fluid collections which may lead to further complications.

Infections

The immunosuppressant effect of Certican 0.25 Tablet may decrease the resistance to infectious agents and may increase the risk of infections. You are advised to report any unusual symptoms such as a sore throat, pain or burning during urination, fever, chills, etc., to the doctor immediately. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Non-infectious pneumonitis

Certican 0.25 Tablet may cause non-infectious pneumonitis. Appropriate dose adjustments should be made based on the severity of the symptoms. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Proteinuria

Certican 0.25 Tablet may increase the presence of abnormal quantities of protein in the urine (proteinuria) when it is used along with cyclosporine in people who have undergone transplant surgeries. Monitoring of protein levels in urine is recommended when these medicines are used together. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Infertility

Prolonged therapy with Certican 0.25 Tablet may cause male as well as female infertility. If you are a person with reproductive potential, discuss this risk with your doctor before beginning treatment with this medicine.

Stomatitis/Mouth Sores

Certican 0.25 Tablet may cause mouth sores. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Hematologic abnormalities

Certican 0.25 Tablet should be used with caution if you are predisposed to hematologic changes due to the increased risk of severe hematologic abnormalities. These abnormalities may include decreased levels of haemoglobin, platelets, lymphocytes, white blood cells, etc. Periodic monitoring of complete blood counts is recommended during treatment with this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Missed Dose

Take the missed dose of Certican 0.25 Tablet as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose of Certican 0.25 Tablet. Seek emergency medical treatment or contact your doctor immediately if you suspect that you might have taken an overdose of this medicine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Aliskiren

Angiotensin converting enzyme inhibitors (ACEI's)

Darunavir

Adalimumab

Ketoconazole

Disease interactions

Liver disease

Certican 0.25 Tablet should be used with caution if you have liver problems due to the increased risk of severe side effects. Your doctor may suggest tests for monitoring your liver condition while on treatment with this medicine. Also, your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Kidney diseases

Certican 0.25 Tablet should be used with caution if you have kidney diseases due to the increased risk of worsening your condition. Your doctor may suggest tests for monitoring your kidney condition while on treatment with this medicine. Also, your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Food interactions

Consumption of grapefruit or grapefruit juice is not recommended during treatment with Certican 0.25 Tablet due to the increased risk of serious adverse effects.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Certican 0.25 Tablet exactly as advised by your doctor. Follow all the usage instructions mentioned on the label/package insert. Do not take in larger amounts than advised. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. While you are taking Certican 0.25 Tablet do not take any vaccinations without consulting your doctor first. Keep Certican 0.25 Tablet away from the reach of children and pets. Ensure that the unused medicine is disposed of properly.

Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works

Certican 0.25 Tablet works by suppressing the immune system which prevents organ rejection after organ transplantation. It also stops cancer cells from multiplying and decrease the blood supply to the cancer cells.

Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Selective immunosuppressants , Mtor inhibitors

Schedule

Schedule H

Ema.europa.eu. 2021. [online] Available at: < [Accessed 18 August 2021].

https://www.ema.europa.eu/en/documents/product-information/afinitor-epar-product-information_en.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 18 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021560s000lbl.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 18 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022334s6lbl.pdf>

Drugs, H., 2021. Everolimus: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 18 August 2021].

https://medlineplus.gov/druginfo/meds/a609032.html>

Dailymed.nlm.nih.gov. 2021. DailyMed - AFINITOR- everolimus tabletAFINITOR DISPERZ- everolimus tablet, for suspension. [online] Available at: < [Accessed 18 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2150f73a-179b-4afc-b8ce-67c85cc72f04>

Related Questions

Question:
Does everolimus elevates crp and esr levels, causes body pain?lever transplant inMay2017. Should I c...more
Answer from Dr. K Shanmuganandan
Yes
Question:
I got lever transplant inMay2017. Taking certican 0.5bd. My crp3 and esr42.Does everolimus causes bo...more
Answer from Dr. N. C. Gupta
Kindly consult the team that operated on you.
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Information on this page was last updated on 16 Nov 2021

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.