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Brufen-MR Capsule
Manufactured byABBOTT HEALTHCARE PVT LTD
ContainsIbuprofen (400 mg) + Tizanidine (2 mg)
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Description
Brufen-MR Capsule is a combination medicine which may be used for the treatment of pain, swelling, and other symptoms associated with muscle spasms. Patients are advised to undergo appropriate physical therapy and rest, as necessary, along with this medicine to obtain the best possible effect.
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Substitutes
List of substitutes for Brufen-MR Capsule
Side effects
Major & minor side effects for Brufen-MR Capsule
Chest pain and discomfort
Nausea and vomiting
Painful or burning urination
Unusual tiredness and weakness
Blurred vision
Irregular heartbeat
Shortness of breath
Weight gain
Constipation
Skin rash
Loss of appetite
Uses of Brufen-MR Capsule
What is it prescribed for?
Acute inflammation and pain associated with muscle spasm
This medicine may be used to treat pain, swelling, and other symptoms associated with muscle spasms. It is also may be used to relieve excessive pain and cramps during menstruation.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The effect of this medicine can be observed within 30 minutes of administration of the dose.How long do the effects of this medicine last?
The effect of this medicine lasts for an average duration of 4 to 6 hours.Is it safe to consume alcohol while taking this medicine?
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, drowsiness, confusion, difficulty in concentrating, a very low blood pressure, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.Is this a habit forming medicine?
No habit-forming tendencies were reported.Can this medicine be taken during pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.Can this medicine be taken while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to ibuprofen, any other NSAIDs, tizanidine, or any other inactive ingredient present in the formulation.
Asthma
This medicine is not recommended for use in patients with a known history of NSAID-induced asthma due to the increased risk of worsening of the patient's condition.
Coronary Artery Bypass Surgery (CABG)
This medicine is not recommended for use before, during, or after a coronary artery bypass graft surgery due to the increased risk of severe adverse reactions.
Gastrointestinal disorders
This medicine is not recommended for use in patients with peptic ulcer disease or any gastrointestinal bleeding disorders due to the increased risk of worsening of the patient's condition.
CYP1A2 inhibitors
This medicine is not recommended for use in patients receiving CYP1A2 inhibitors such as fluvoxamine due to the increased risk of severe adverse effects.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
General warnings
Hypotension
This medicine should be used with caution in patients with hypotension (low blood pressure) or patients predisposed to hypotension due to the increased risk of hypotensive episodes. Appropriate dose adjustments and close monitoring of blood pressure may be required for such patients.
Kidney impairment
This medicine should be used with caution in patients with kidney impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function and appropriate dose adjustments may be necessary based on the clinical condition.
Liver impairment
This medicine should be used with caution in patients with liver impairment due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is recommended for such patients. Therapy may need to be discontinued based on the clinical condition.
Driving or operating machinery
Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Gastro-intestinal toxicity
This medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. This risk is especially higher in patients with a history of gastrointestinal diseases. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Coronary Artery Bypass Surgery
This medicine should not be taken to relieve pain before or after undergoing a coronary artery bypass graft surgery due to the increased risk of severe adverse reactions.
Asthma
This medicine is not recommended for use in patients with a known history of NSAID-sensitive asthma.
Missed Dose
Take the missed dose as soon as you remember. The missed dose should be skipped if it is almost time for the next scheduled dose. Do not use extra medicine to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, drowsiness, confusion, difficulty in concentrating, a very low blood pressure, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine
Corticosteroids
Antihypertensives
Benazepril
Methotrexate
Clozapine
Amiodarone
Aspirin
Disease interactions
Asthma
This medicine is not recommended for use in patients with a history of NSAID-sensitive asthma. Replacement with a suitable alternative should be done under your doctor's supervision.
Fluid Retention and edema
This medicine may cause fluid retention and edema in some patients. Close monitoring of blood pressure, electrolyte levels, and heart function may be required based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases.
Skin Rash
This medicine may cause fatal skin allergies without any warnings in some patients. Signs and symptoms such as rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Renal Dysfunction
This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of the kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Liver Disease
This medicine should be used with caution in patients with liver diseases due to the increased risk of liver injuries. Liver function should be assessed before initiating treatment. Close monitoring of liver function may be necessary during treatment with this medicine. Therapy may need to be discontinued based on the clinical condition.
Food interactions
Consumption of caffeine may increase the undesired effects of this medicine. This may cause side effects such as drowsiness, dizziness, lightheadedness, fainting, irregular heartbeat, etc. Hence, you are advised to avoid the consumption of caffeine during treatment with this medicine.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
Ibuprofen works by inhibiting the chemical substances in the body that causes pain and swelling. Tizanidine acts on the nervous system and reduces muscle spasms, allowing the muscles to relax.
Legal Status
Classification
Category
Non-steroidal anti-inflammatory agents, Skeletal muscle relaxants
Schedule
Schedule H
Tizanidine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 30 August 2017]. Available from:
Tizanidine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 30 August 2017]. Available from:
Ibuprofen: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 16 May 2019]. Available from:
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Information on this page was last updated on 21 Jun 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.