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Baclofen

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Description

Baclofen is an Antispastic agent which is used to relieve pain and improves the muscle movement. It should be started at low doses and increased gradually based on the response. Do not stop abruptly due to the risk of seizures.
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Side effectsConcernsUsage

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Side effects

Major & minor side effects for Baclofen

Ringing or buzzing in the ears

Change in mood

Skin rash

Confusion

Dizziness

Nausea or Vomiting

Muscle weakness

Headache

Constipation

Difficult or painful urination

Uses of Baclofen

What is it prescribed for?

Spasticity

Baclofen is used in the treatment of spasticity caused due to the brain or spinal cord injury characterized by stiffness of muscles and interferes with normal body movement.
Concerns

Commonly asked questions

  • Onset of action

    The peak plasma concentration can be achieved in 2 to 3 hours. It takes 3 to 4 days for the medicine to show its effect.

  • Duration of effect

    The medicine stays in the body for an average duration of 7 to 12 hours.

  • Safe with alcohol?

    Consumption of alcohol with this medicine is not recommended as it can result in dizziness and difficulty in concentration. Avoid activities that need mental alertness like driving and operating machinery.

  • Is it habit forming?

    No habit forming tendency has been reported

  • Usage in pregnancy?

    This medicine is not recommended for pregnant women unless necessary. The benefits and risks should be discussed with the doctor before taking this medicine.

  • Usage while breast-feeding?

    This medicine is known to excreted through the breast milk. It is not recommended in breastfeeding women unless necessary. Monitoring of symptoms like sedation is necessary.

Allergy

Not recommended in patients with known allergy to Baclofen.

Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women unless necessary. The benefits and risks should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is known to excreted through the breast milk. It is not recommended in breastfeeding women unless necessary. Monitoring of symptoms like sedation is necessary.

General warnings

Abrupt withdrawal

This medicine may cause hallucinations and seizures if stopped abruptly. The dose should be reduced gradually over a period of 1 to 2 weeks based on patients response.

Central nervous system disorders

This medicine may worsen the conditions like schizophrenia depressive or manic disorders, confusional states or Parkinson's disease. It should be used with caution in these patients. Inform the doctor if any symptoms appear.

Impaired kidney function

The concentration of this medicine may increase in patients with kidney disease. The kidney function should be monitored carefully. The dose should be adjusted based on the CrCl.

Ovarian cysts

Ovarian cysts were found in patients being treated with this medicine for up to one year and disappeared later.

Missed Dose

Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Use of this medicine with alcohol will cause depression of the central nervous system and respiratory system.

Instructions

Consumption of alcohol with this medicine is not recommended as it can result in dizziness and difficulty in concentration. Avoid activities that need mental alertness like driving and operating machinery.

Interaction with Medicine

Clobazam

Opioids

Antihypertensives

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with the kidney disease due to increase in the concentration of this medicine and increase in the risk of adverse effects. Close monitoring of kidney function is necessary. The dose should be adjusted based on the CrCl.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Baclofen as advised by the doctor at the same time every day. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking this medicine without consulting the doctor due to the risk of seizures and hallucinations.

Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works

It works by inhibiting the release of the chemical at the spinal level and relieves pain and improves the muscle movement.

Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Skeletal muscle relaxants

Schedule

Schedule H

Baclofen - DrugBank [Internet]. Drugbank.ca. 2017 [cited 17 May 2017]. Available from:

https://www.drugbank.ca/drugs/DB00181

[Internet]. 2017 [cited 17 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/29220

DailyMed - Baclofen injection [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 17 May 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=327fad73-15a2-0507-e054-00144ff8d46c

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 17 May 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 17 May 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~Gv5Nsm:1
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Information on this page was last updated on 16 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.