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Amphotericin B (Colloidal dispersion)

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Description

Amphotericin B (Colloidal dispersion) is an antifungal medicine used to treat serious and potentially life-threatening infections caused by different fungal species. The colloidal dispersion form of this medicine is used in patients who do not respond or are unable to tolerate the conventional form of this medicine.
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Side effectsConcernsUsage

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Side effects

Major & minor side effects for Amphotericin B (Colloidal dispersion)

Chills and fever

Headache

Nausea and Vomiting

Difficulty in breathing

Loss of appetite

Stomach pain

Pain at injection site

Joint pain

Diarrhea

Uses of Amphotericin B (Colloidal dispersion)

What is it prescribed for?

Visceral Leishmaniasis (Kala Azar)

This medicine is used for the treatment of Visceral Leishmaniasis, a parasite infection caused by the Leishmania parasites.

Febrile Neutropenia

This medicine is used to treat the development of fever in patients with neutropenia (low number of neutrophils in the blood).
Concerns

Commonly asked questions

  • Onset of action

    The amount of time required for this medicine to show its action is not clinically established.

  • Duration of effect

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Safe with alcohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendency has been reported.

  • Usage in pregnancy?

    This medicine is recommended for use in pregnant women only if absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

  • Usage while breast-feeding?

    This medicine is relatively safe for use in breastfeeding women. However, all the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Amphotericin B (Colloidal dispersion) or any other components present along with it.

Warnings for special population

Pregnancy

This medicine is recommended for use in pregnant women only if absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is relatively safe for use in breastfeeding women. However, all the risks and benefits should be discussed with the doctor before receiving this medicine.

General warnings

Nephrotoxic medicines

This medicine should be used with caution in patients taking nephrotoxic medicines due to the increased risk of worsening of the patient's condition. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Antineoplastics

This medicine should be used with caution in patients taking antineoplastics due to the increased risk of renal toxicity, bronchospasm, or hypotension. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Leukocyte transfusions

This medicine is not recommended for use in patients receiving leukocyte transfusions due to the increased risk of acute pulmonary toxicity. Replacement with a suitable alternative may be necessary based on the clinical condition.

Infusion reactions

This medicine may cause infusion reactions such as a headache, fever, chills, loss of appetite, nausea, or vomiting with the first few doses. These reactions usually diminish with subsequent doses.

Anaphylaxis

This medicine may cause serious anaphylactic reactions. Appropriate corrective measures should be undertaken in the event of any anaphylactic reactions. Therapy may be discontinued based on the clinical condition.

Missed Dose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Corticosteroids

Cyclosporine

Zidovudine

Disease interactions

Disease

Information not available.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
This medicine should be administered only by a qualified healthcare professional. Carefully follow all the instructions given by your doctor. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.

Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works

Amphotericin B (Colloidal dispersion) works by blocking the action of a certain vital component of the fungal cell wall. This results in disruption of cell membrane and death of the fungus.

Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Polyenes

Schedule

Schedule H

[Internet]. 2017 [cited 11 September 2017]. Available from:

https://www.bharatserums.com/product/critical/AMPHOMUL%2050mg%20Pack%20Insert%20for%20Domestic.pdf

Amphotericin B - DrugBank [Internet]. Drugbank.ca. 2017 [cited 4 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB00681

Amphotericin B colloidal dispersion. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 13 September 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/11249532
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Information on this page was last updated on 13 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.