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Aminophylline
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Description
Aminophylline is a very effective bronchodilator medicine. It relaxes the smooth muscles of the airways leading to the lung. This medicine is used to prevent and treat wheezing, shortness of breath, chest tightness associated with lung diseases like asthma, chronic bronchitis, emphysema etc.
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Side effects
Major & minor side effects for Aminophylline
Increased/Irregular heart rate
Convulsions (seizures)
Allergic Skin Reaction
Stomach discomfort and pain
Diarrhea
Headache
Sleeplessness
Swelling of ankles or feet
Yellowing of skin and eyes
Increased urination frequency
Twitching and unusual movement of muscles
Elevated liver enzymes
Uses of Aminophylline
What is it prescribed for?
Asthma (Acute)
This medicine is used for the prevention and treatment of symptoms associated with chronic asthma. Symptoms may include wheezing, chest tightness and difficulty in breathing. It is used in conjugation with other medicines to treat emergency conditions.
Other lung diseases causing bronchospasms
This medicine is also used to treat airway blockage associated with other disease of the lungs like chronic bronchitis, emphysema etc. It is used in conjugation with other medicines to treat emergency conditions.
Concerns
Commonly asked questions
Onset of action
The amount of time taken for this medicine to show its effect is subject to vary based on the form of medicine consumed.Duration of effect
The time duration for which this medicine remains effective in the body is subject to variations based on the form of medicine consumed.Safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is it habit forming?
No habit forming tendencies were reported.Usage in pregnancy?
This medicine is not recommended for use by women who are pregnant unless absolutely necessary and the benefits outweigh the risks associated. Consult your doctor before using this medicine.Usage while breast-feeding?
This medicine is not recommended for use by women who are breastfeeding unless necessary. Consult your doctor and discuss the risks associated with use before taking this medicine.
Allergy
This medicine is not recommended for use if you have a known history of allergy to aminophylline or any other xanthine derivatives. It should not be used if you are allergic to ethylenediamine, which is a secondary constituent in the medicine.
Warnings for special population
Pregnancy
This medicine is not recommended for use by women who are pregnant unless absolutely necessary and the benefits outweigh the risks associated. Consult your doctor before using this medicine.
Breast-feeding
This medicine is not recommended for use by women who are breastfeeding unless necessary. Consult your doctor and discuss the risks associated with use before taking this medicine.
General warnings
Other diseases
Report the instance of any disease of the heart and blood vessels, brain, thyroid glands etc to the doctor before receiving this medicine. This medicine should be used with caution and any disease worsening symptom should be reported to the doctor immediately.
Other medicines
This medicine is known to interact with a large number of other medicines. Report the use of all medicines including herbs and supplement to the doctor.
Smoking
This medicine tends to be less effective if you smoke or consume tobacco products. Avoid or limit the uptake of tobacco products while taking this medicine.
Caffeine
Consumption of caffeine while taking this medicine may cause certain side effects to appear. Avoid or limit the uptake of caffeine or caffeine products while taking this medicine.
Fever and infections
This medicine should be used with caution if you have a high fever (febrile) with a headache, chills, and joint pain. Report any such instance to the doctor while taking this medicine.
Toxic accumulation of the medicine
Use of high doses of this medicine has been associated with toxicity due to an accumulation of the medicine in the body after long term use. It is advised to measure the serum levels and withhold the dose of this medicine if toxicity symptoms are developed.
Use in the elderly
This medicine should be used with caution in the elderly as the risk of adverse effects are significantly higher.
Acute asthma attack
It is advised to take an alternate and fast-acting medicine to treat an attack of asthma that has already set in.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.
Overdose
Contact your doctor immediately if an overdose with aminophylline is suspected. The overdose may occur due to excessive uptake at one time or exposure to high doses over a long period of time. Symptoms of overdose may include fever, nausea and occasional vomiting, lack of sleep, agitation etc. An overdose of this medicine can cause severe seizures and even death.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Carbamazepine
Fluvoxamine
Lithium
Phenytoin
Propranolol
Ethinyl Estradiol
Azithromycin
Cimetidine
Ciprofloxacin
Riociguat
Disease interactions
Peptic ulcer
This medicine should be administered with caution in patients with active peptic ulcer disease. As the risk of worsening of symptoms is very high, your doctor will determine the best course of treatment after assessing the condition.
Kidney Disease
This medicine should be used with caution in patients suffering from an impairment of kidney functions. Appropriate dose adjustments and intensive monitoring may be required if the impairment is moderate to severe.
Seizure disorders
This medicine should be used with caution in patients suffering from seizure disorders. Appropriate medicine to control seizure should be given before starting the treatment with this medicine.
Heart rhythm disorders
This medicine should be used with caution in a patient suffering from a heart rhythm disorder. Suitable clinical investigations should be performed to determine the safe and effective use of this medicine.
Porphyria
This medicine should be used with caution in patients suffering from this rare genetic disorder of the blood and the skin.
Food interactions
Avoid or limit the uptake of caffeine while taking this medicine. Report any incidence of an adverse effect to the doctor on priority.
Avoid consumption of tobacco and marijuana while taking this medicine. The risk of adverse effects is high even with secondhand smoking.
Lab interactions
Information not available.
Take Aminophylline as instructed by the doctor. Do not take more or less of this medicine or take it for longer or shorter duration than recommended by the doctor. This medicine should be taken 1-2 hours before meals. It is advised to take this medicine for the entire prescribed duration of time.
Miscelleneous
How it works
This medicine works by relaxing the smooth vessels of the airways in the lungs. It also reduces the sensitivity of lungs to allergens that cause irritation and constriction of muscles in the chest and the lungs. It also causes the contraction if diaphragm (the breathing muscle present below the lungs).
Legal Status
Classification
Category
Methylxanthines
Schedule
Schedule H
Aminophylline - DrugBank [Internet]. Drugbank.ca. 2017 [cited 19 May 2017]. Available from:
Aminophylline | C16H24N10O4 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 19 May 2017]. Available from:
Aminophylline: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 May 2017]. Available from:
DailyMed - Aminophylline injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 19 May 2017]. Available from:
Information on this page was last updated on 16 Nov 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.