What was the age in which she was diagnosed disease and what was her marker status - ER , PR and HER 2 . Was she confirmed to have BRCA mutation positive ? Yes it definitely may have significance , since getting full picture will help family members and she can also prevent further malignancy by taking proper prophylactic measures. To give you exact reason for the advise and to give you the correct advice on how to proceed need further detailed of her case and your family history . You can consult me with above details for risk evaluation.