Diabetes and other diseases that impair the immune system — the body's defense against germs — can increase the risk of UTIs. If you have frequent UTIs, your doctor may make certain treatment recommendations, such as: Low dose antibiotics, initially for six months but sometimes longer Self-diagnosis and treatment, if you stay in touch with your doctor A single dose of antibiotic after sexual intercourse if your infections are related to sexual activity.... Antibiotics usually are the first line treatment for urinary tract infections. Which drugs are prescribed and for how long depend on your health condition and the type of bacteria found in your urine....