My wife was diagnosed with tuberculoma (brain tb) around 19 months ago. Initially medication was started with pyrazinamide 1500 mg  rifampin 450 mg isoniazid 450 mg ethambutol 1000 mg and dexamethasone 18 mg for first four months. Then ethambutol was dropped and rest three were continued for next 8 months. After 1 year, MRI scan showed good progress so pyrazinamide was also dropped and rest two drugs were continued for next 7 months. Subsequently, latest MRI scan on 15 Sep 2020 has shown an increase in the infection with no major clinical symptoms except mild headaches. Is it possible that infection can increase inspite of continuing medication as mentioned above. Latest PET scan report is normal.