Hi, both can cause sedation.

Yes, clonazepam and mirtazapine can be prescribed together, but usually for short-term use under strict supervision. Mirtazapine treats sleep maintenance/insomnia, while clonazepam helps with acute sleep-onset anxiety. The combination increases CNS depression, leading to cumulative sedation, morning drowsiness, and impaired motor skills. Next Steps * Review the dosage and treatment duration with your doctor. * Take the doses right before bed as directed. * Plan for regular follow-ups to taper clonazepam once sleep improves. Helpful Tips / Word of Caution * Avoid alcohol or additional sedatives. * Do not drive or operate machinery if feeling groggy. * Do not stop clonazepam suddenly to prevent withdrawal.