Everyone has two copies of the haemoglobin gene in every cell in their body (apart from eggs and sperm). They get one from their mother and one from their father. When eggs and sperm are made, only one of the two genes goes into each egg or sperm cell. This is so that when the egg and sperm come together to make a new baby this new person has two genes in every cell in their body as well. The genes the baby gets will therefore depend on the genes carried in its parents.
Sickle Cell Anaemia is called a recessive condition because you must have two copies of the sickle haemoglobin gene to have the disorder. Sickle haemoglobin is often shortened to S or HbS. If you have only one copy of the sickle haemoglobin along with one copy of the more usual haemoglobin (A or HbA) you are said to have Sickle Cell Trait. This is not an illness but means that you “carry” the gene and can pass it on to you children. If your partner also has Sickle Cell Trait or Sickle Cell Anaemia your children could get Sickle Cell Anaemia.
If you know the types of haemoglobin you and your partner have, you will know the different possible combinations of genes that your baby could inherit. Only when both parents are HbAA and/or HbSS will all your children inherit the same combination of genes so you can be sure whether your child will be affected or not.
If one parent has sickle cell trait (HbAS) (like in ur case) and the other does not carry the sickle haemoglobin at all (HbAA) then none of the children will have sickle cell anaemia. There is a one in two (50%) chance that any given child will get one copy of the HbS gene and therefore have the sickle cell trait. It is equally likely that any given child will get two HbA genes and be completely unaffected.
So don’t worry. Relax
Answered2020-05-25 15:30:13
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