Here's a polished version of your question: "My 40-year-old sister-in-law has been suffering from a severe vaginal infection, characterized by intense itching (similar to psoriasis) at night, followed by heavy pain while urinating and washing. She has been experiencing these symptoms since childhood, but they have worsened over time, affecting her mental health and leading to depression. Despite trying various medications, her condition remains unchanged. What are the next steps for treatment?"