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Hello, I am Dr. Romain Rajan, General Physician. Your case has been allotted to me. I understand your concern. You are taking methylene blue in water as a dietary supplement for cognitive benefit and want professional advice on dosing and safety before continuing. 1. Advices Stop self administering methylene blue until you have a clear plan with a doctor. Do not combine methylene blue with antidepressants such as SSRIs, SNRIs, tricyclics, MAO inhibitors or with tramadol and certain migraine drugs because of the risk of serotonin syndrome. If you are known or may be G6PD deficient do not take methylene blue as it can cause hemolysis. Avoid use during pregnancy or breastfeeding unless supervised by a specialist. 2. What to Monitor New symptoms such as agitation, tremor, high body temperature, fast heartbeat, sweating or confusion which may indicate serotonin syndrome. Dark or blue green discoloration of urine and body fluids which is common but alarming to patients. Signs of hemolysis such as sudden weakness, dark urine, yellowing of eyes or rapid drop in hemoglobin. Any new abdominal pain, nausea, vomiting or dizziness. 3. Management Evidence summary and dosing reality Methylene blue has plausible mechanisms for neuroprotection in lab studies and some early human studies show promise. However methylene blue is not an approved dietary supplement for cognitive enhancement and there is no widely accepted oral dosing guideline for this use. Dosing and formulations in published research vary and are not standardized. Practical recommendation Do not continue unsupervised use. Discuss with your GP or a specialist before restarting. If your GP and a specialist agree to a trial, it should be under medical supervision with baseline tests such as G6PD level and liver and renal function and careful review of all concomitant medicines. Consider alternative evidence based and safer measures for cognition such as good sleep hygiene, regular aerobic exercise, Mediterranean style diet, blood sugar control, cognitive training and approved supplements when indicated. If your GP remains conflicted consider a short specialist consultation with a clinical pharmacologist or neurologist experienced in neurotherapeutics to review risks and possible monitored dosing. 4. When to Consult a Doctor Immediately If you develop fever, muscle stiffness, tremor, confusion or rapid heart rate. If you notice dark urine, sudden pallor, jaundice or breathlessness. If you develop severe nausea, vomiting or fainting. Every patient’s situation is unique. For a personalised and safe plan please discuss your full medication list and medical history with your GP or book a one on one consultation with me. 👉 You can reach out to me directly for this case and also connect with me in future for any medical consultation. I am available on Practo or on WhatsApp at 85271646 seven seven for a one on one consultation, where you will receive • A personalised review of your medicines and risks • Tests to ensure safety if a supervised trial is considered • Close follow ups to monitor for side effects Take care, wishing you good health. Best regards, Dr. Romain Rajan General Physician

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It is not advised as nutritional supplement.

It is not advised under medical guidelines

Need few more details Kindly connect.

Methylene blue is not advised as a supplement It will give a fatal results with serotonins So better avoid it as a food supplement

It has very potential side effects. It should be taken under supervision. Better to avoid at young age.

Can help you with the next course of action and treatment plan. Kindly consult via whatsapp at nine zero two nine six zero zero four seven zero.

Hey, kindly consult with me on 94 two six eight six 78 nine six so that we can discuss it in detail. This needs urgent addition.

You got a detailed response already

Hi 👋 I appreciate that you’re doing your homework before continuing — that’s exactly how you should approach something like methylene blue (MB), because while it’s an old and fascinating compound with legitimate medical use, its use as a “nootropic supplement” is not evidence-based or risk-free. What methylene blue actually is Methylene blue is a prescription drug, not a nutritional supplement. It’s used in hospitals for: Methemoglobinemia treatment (to restore normal oxygen-carrying ability of blood) As a urinary antiseptic and dye in diagnostic procedures Sometimes experimentally in Alzheimer’s, mitochondrial disorders, and sepsis (under strict monitoring). Its “cognitive” benefit claims mostly come from in-vitro or small animal studies that suggest mitochondrial and antioxidant support. Human data are small, inconsistent, and dose-dependent — benefits are speculative; it’s far from a proven brain booster. The real risks you should know At doses even close to what you’re using, MB can: 1. Interfere with serotonin metabolism, causing serotonin syndrome if you’re on SSRIs, SNRIs, or MAOIs (serious risk). 2. Cause hemolysis in people with G6PD deficiency — leading to anemia or jaundice. 3. Lead to urinary irritation, nausea, confusion, blue discoloration of skin/urine, and in higher doses, even cardiac effects. 4. At chronic low-dose use, it may accumulate in tissues (especially in the CNS and liver), and there’s no long-term human safety data for such “microdosing.” The “0.1%” solution you’re using means 1 mg/ml. So, 2.5 ml = 2.5 mg/day — sounds small, but it’s still pharmacologically active. There’s no standardized “safe supplement dose” published by WHO, FDA, or ICMR for this use. Bottom line (evidence summary) Cognitive benefits: unproven, mostly theoretical. Risks: real and dose-dependent. Safe long-term use data: absent. In India, MB is not approved as a dietary or cognitive supplement. If you continue without supervision, you’re essentially doing self-experimentation with a drug that can alter blood chemistry and neurotransmitter levels. My professional advice Stop using it as a supplement unless under the supervision of a doctor familiar with methylene blue pharmacology. If you’re keen to explore it for mitochondrial or cognitive reasons, get the following first: G6PD test (to rule out risk of hemolysis). Medication review to check for drug interactions. Liver and kidney function tests if you’ve used it more than a week. There are safer, better-studied options for cognitive support (like structured sleep optimization, omega-3s, or acetyl-L-carnitine). Summary You’re using a medically active dye — not a harmless supplement. It may give a transient “focus” feeling but carries risks that outweigh unproven benefits. My recommendation: stop for now, get basic tests done, and then we’ll discuss a safer, evidence-backed brain-support plan. If you’d like, I can review your exact product formulation and daily intake, check for potential drug interactions, and tell you if any tapering or wash-out period is needed before stopping. You can message me directly on WhatsApp at nine three two six zero two zero five three six — I’ll personally guide you with a clear plan on how to safely discontinue or transition to evidence-based cognitive strategies.

Now you consume 2.5 mg of methblue its subnormal level.. Do increase with time to 10 mg Go for blood test one month later ( CBC ESR LFT KFT) Effect of renal system and liver

Interestingly something new for me and many other doctors too. I would love to know about it more will be doing some research on it. If you feel like discussing about something feel free to connect  eight three six eight seven two eight one three seven

Avoid fri3d and spicy food. Water intake more

Can help you, kindly consult and provide detailed history for proper diagnosis and further management

If you require assistance or have any health concerns, feel free to reach out for a consultation. Your well-being is my priority, and i'm here to support you on your health journey.