My father-in-law has had an elevated white blood cell (WBC) count of around 37,000 for the past 4 years. Two years ago, we performed all the relevant tests—bone marrow biopsy (negative), karyotyping (normal), and a comprehensive myeloid panel (negative). Since no mutation was detected at the time, the doctors didn’t prescribe any medication. Recently, we repeated the tests and were advised to perform an MPN panel. The results showed a clinically significant JAK2 Exon 14 variant with sequencing VAF 30.04%, depth 66034X, Tier 1B. Although my father-in-law's general health is stable, he occasionally experiences fatigue. The hematologist has now recommended: - Aspirin Ecosprin 75 mg once daily for 30 days - Hydroxyurea Myelostat 500 mg twice daily for 30 days We’re seeking confirmation whether these medications are appropriate, and specifically want to understand any potential side effects of taking Aspirin daily. Regards, Pavitha