My father had a brain surgery[csf ottorhea] 5 months ago,he has an infection [pseudomonas ] come from hospital which couldn't cured after giving lots of antibiotics which are sensitive shown in csf culture, but no improvement seen.approx 15 days after operation there seen a swelling in brain,and my father became unconscious and breathing problems.doctors adviced to do MRI . MRI shows there is hydrocephalus developed in brain.then doctors adviced to do Vp shunt operation.after operation he is liitle bit consious and we discharge him from hospital.but after some days he again becomes unconscious and infection is still there..now what should we do? Antibiotics  given for infection are as follows; Meopenum 1.polymyxin 2.minocycline 3.vancomycin 4.micafungene 5.amphotericin 6.zavicefta 7.colistin 8.fosfomycin