If an animal known or suspected to be rabid, individuals who have previously received a complete series of pre- or post-exposure rabies vaccine (with cell-culture or embryonated-egg vaccine) should receive two booster doses of vaccine. Ideally, the first dose should be administered on the day of exposure and the second 3 days later. This should be combined with thorough wound treatment. Cleaning wound with soap and water. Applying betadine solution. Rabies immunoglobulin is not required for patients who have previously received a full vaccination.