Im having swelling and pain in ankle joints. Diagnosed as Sero negative arthritis...treatment with Folitrax 15 once a week by rheumatologist..I've a doubt. I.e Why does joint pains in arthritis increase few days before periods in ladies?generally for how long duration is Methotrexate prescribed for arthritis treatment? Can it be taken for more than 1 year if under supervision of rheumatologist?how can swelling of joints be reduced? And usually are these immuno suppressants supposed to be taken lifelong or is it stopped after few years?