ANA positive could be seen in a number of conditions with autoimmune pathology like SLE, Sjogren’s, Rheumatoid arthritis, systemic sclerosis. Serious or not should be the query , evaluate further regarding. Doing a full Ana profile and other routine investigations to see for other systems involvement. More information regarding symptoms and reason for ANA testing would help giving a more complete answer
Next Steps
Compete ANA profile , CBC, RFT Urine routine and rheumatology consult
Health Tips
More complete history would help