To say whether it's significant or not we need to check the weight gain since birth. Kindly provide with the birth weight and present weight.

Babies have very tiny stomach and hence tend to vomit the extra amount consumed. Some do it rarely and some very often. To know whether this vomiting is problematic you will have to keep a track of her weight at regular intervals. If she is gaining weight regularly you don't have much to worry about other than the soiled clothes!