Keep your groin area dry. Dry your genital area and inner thighs thoroughly with a clean towel after showering or exercising. Use powder around your groin area to prevent excess moisture. Wear clean clothes. Change your underwear at least once a day or more often if you sweat a lot. Wash workout clothes after each use. Be cool. Don't wear thick clothing for long periods of time in warm, humid weather.an over-the-counter antifungal ointment, lotion, powder or spray. The rash may clear up quickly with these treatments, but continue applying the medication twice a day for at least 3 weeks...Consult dermatologist for further assistance.