Before two months my wife suffering from severe lower back and shoulder pain, shivering ,sweating and weaknesses. Then checked CBC TSHsugar Ultrasound vit B 12 find neg but found vit D difficient it's 6.5 but later 1.5 when checked found 106. But within period she suffer depression, abnormal activity in night. We consult Nerurologist after 1 days treatment that cleared. But again lower back pain started and severed right leg pain started when she long seating and when came from toilet. Some time she unconscious for 25 to 20 min. We consult orthopaedic we did brain MRI lumar spine MRI , X rays, sonography, ECG, CBC TSH suar test, Urine culture, CRP RA factor HLA b27 all found normal. Doctor told problem not from Orthopaedic consult Neruro Physio. Again consult neurologist started treatment . LONAZEP, GABA 100 ,CAL AND VIT D3, BETAVERT 16 INDOMETHACINE,cyanocobalamin and folic acid. During this two month she has no periods so consult Gyano doctors suggest meprate and tranexamic acid 50