The 16 × 5.5 mm gallbladder calculus does not by itself indicate surgery. Cholecystectomy is indicated if the patient has typical biliary symptoms such as recurrent RUQ/epigastric postprandial pain, nausea/vomiting, or complications such as acute cholecystitis, pancreatitis, or choledocholithiasis. If asymptomatic, conservative management is appropriate. The mildly elevated bilirubin (1.68 mg/dL) and GGT (56 U/L) may be related to transient biliary obstruction, but they are not sufficient to diagnose CBD stone. AST/ALT are not significantly elevated. Review the ultrasound specifically for CBD diameter and intrahepatic biliary dilatation. If CBD is dilated or cholestatic parameters remain elevated/worsen, MRCP/EUS should be considered to exclude choledocholithiasis. ERCP should be reserved for confirmed/high-probability CBD obstruction or cholangitis. Grade-2 hepatomegaly may be associated with fatty liver, but hepatomegaly alone does not confirm it. Assess hepatic steatosis on ultrasound and evaluate metabolic risk factors. Treatment is primarily lifestyle modification and management of metabolic risk factors. The chronic bilateral pitting pedal edema is unlikely to be explained by the gallstone and requires separate evaluation for renal, cardiac, hepatic, thyroid, medication-related and venous causes.

A gallstone is considered symptomatic if you experience biliary colic (sharp or cramping pain in the upper right abdomen or epigastrium, often after fatty meals), bloating, or nausea. If you have these symptoms, an elective laparoscopic cholecystectomy is indicated. If you have no abdominal symptoms, it is an incidental, asymptomatic gallstone and generally does not require immediate surgery. Grade 2 fatty infiltration (hepatic steatosis) is the most common cause of painless hepatomegaly in young adults. It requires lifestyle intervention (weight management, balanced diet, exercise) and monitoring. A gallstone in the gallbladder usually does not cause elevated bilirubin or GGT unless a smaller stone/sludge has migrated into the Common Bile Duct (CBD), causing partial biliary obstruction. Alternatively, mild transaminase elevation (ALT 46.4) and GGT (56 U/L) are very frequently seen in non-alcoholic fatty liver disease. Persistent leg swelling for 6 months is not caused by a gallbladder stone. It requires systemic evaluation for Hypoalbuminemia, Renal etiology, Cardiac or venous insufficiency issues. Review your ultrasound report for the Common Bile Duct (CBD) diameter. If the CBD is dilated (>6 mm) or obscured, an MRCP (Magnetic Resonance Cholangiopancreatography) should be done to confirm or rule out choledocholithiasis (CBD stones). Pease consult a Gastroenterologist, for examination and necessary investigations. Seek immediate medical attention if you develop high-grade fever with chills, worsening upper right abdominal pain, or visible yellowing of your eyes/skin (jaundice), as these may indicate acute cholecystitis or ascending cholangitis.

It’s the patient who tells whether gall stone is symptomatic or not …ask the patient if he/she is having pain in right upper abdomen or nausea/bloating etc if answer is yes then it’s symptomatic and any symptomatic stone need surgery .liver enzyme might be raised due to fatty liver or gall stone passing through common bile duct (CBD) and causing partial obstruction there .See the diameter of CbD /comment on CBd in ultrasound if it’s not given get an MRCP done .if liver enzymes are raised due to fatty liver then it needs further evaluation and treatment (Grade 2 is fatty liver grade only that is causing hepatomegaly )

Symptomatic Gall Stone need planned operation. Pitting edema in legs multifactorial. In your case protein/albumin,KFT to be checked. Derangement of liver function may cause low albumin and oedema. Physical consultation required.