My mother was taking metformin gliclazide and pioglitazone triple drug combination since many years. Simultaneously she was also taking nebivolol and hydrochlorothiazide combination. So there is no edema developed due to pioglitazone because of hydrochlorothiazide medicine is running. But 6 months ago endocrinologist has changed medicine from nebi H to Nebi . Then my mother has developed swelling and edema in legs. Creatinine is normal Echo is normal Venous doplar both legs are normal Ddimer is normal Tsh is normal Hb1ac 6.7 So he  changed treatment like below Pioglitazone is  stopped and metformin and gliclazide is continue and sitagliptin is added. Nebivolol is stopped and chlorthalidone 6.5 mg is added. Today we have done CXR It's showing bilateral prominent bronchovascular markings Do we need to worry sir Because there are few cases reported that pioglitazone can cause pulmonary edema. Prominent bronchovascular markings is due to pulmonary edema? do we need to any further test ?