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Nimsulide is avoided in pregnancy

Occasional use is safe when not pregnant.

Hello, I completely understand that when you are actively trying to conceive, every little medication you take can make you second-guess yourself and worry. Please take a deep breath you have nothing to panic about regarding that one tablet. Here are the direct answers to your questions so you can put your mind at ease: The single dose you took: Taking one Nimesulide tablet for a headache will not ruin your chances of conceiving this month. The medication clears out of your system very quickly, and a single, isolated dose is highly unlikely to interfere with your cycle, ovulation, or implantation. Can you take it regularly while trying to conceive? No, it is best to avoid it going forward. Nimesulide belongs to a group of painkillers called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). If taken frequently especially right around the time you are supposed to ovulate NSAIDs can sometimes temporarily block the egg from releasing properly from the ovary. They can also make the uterine lining slightly less welcoming for a fertilized egg to implant.