Thanks for the query. Nevus of Ota is a difficult condition to treat, but promising results can be achieved. The first step is to do a skin biopsy to determine the exact location of the nevus among various layers of the skin so that depth of laser machine can be decided. Targeting through a single agent may not always be fruitful. Meet a qualified Dermatologist to learn more about the diagnosis and treatment options. Combination of different therapeutic agents is always beneficial. Revlite I.e. Q-switched Nd YAG laser has been available for stubborn pigmentation and can also be combined with fractional CO2 laser if needed.