Treatment depends on the cause, the size of the goitre, and whether it is causing symptoms. For example: Iodine replacement is given if the goitre is due to lack of iodine in the diet... If you have a small goitre that is not due to a cancerous nodule, and your thyroid is making the correct amounts of thyroid hormones then you may not need any treatment.You will need treatment if you make too much or too little of your thyroid hormones.An operation to remove some or all of the thyroid may be an option in some cases....Radioactive iodine treatment may be an option for a goitre causing an overactive thyroid: This involves taking a drink, or swallowing a capsule, which contains radioactive iodine....