Hello, Depo-Medrol (methylprednisolone acetate) is an anti-inflammatory glucocorticoid used to treat pain and swelling that occurs with arthritis and other joint disorders, and many other diseases too. . Common side effects of Depo-Medrol include nausea, vomiting, heartburn, headache, dizziness, trouble sleeping, appetite changes, increased sweating, acne, or pain/redness/swelling at the injection site. Depo-Medrol may also cause a rise in blood
sugar, and it may lower your ability to fight infections. If you take it for short duration and with low dose (as needed) can decreases the side-effects.