Sir I am OCD patient 20 years old.My psychiatrist prescribe me fluvoxin 50 (Fluvoxamine50) in morning and syconil 25 mg( Clomipramine 25mg ) half tab means 12.5 mg with fluvoxin 50 in night...one day i replace syconil 25 mg ( clomipramine 25,colour =  erythrosine ) with clonil 25 mg ( Clomipramine 25 colour = lake of quinoline yellow and titanium di oxide ) Then I feel hypnotic jerk every night. Then I told to my psychiatrist... He said that in psychiatry if you replace medicine that have different colour and  excipients you may feel some change in mood or behavior and thinking also although the power and salt are same... But if medicines having different colours you may feel difference?? So when I came to my initial medicine then my problem of jerk was solved. Is colour of  TCA antidepressants play important role... SO WHY clonil 25 mg ( quinoline yellow  titanium di oxide) clofranil 25 (same salt but colour brillient blue and titanium di oxide ) results different although same salt?