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It is generally not advisable to combine both together because of risk of common side effects like increased drowsiness , sedation to a rare intercation of seizure especially with history of seizure disorder. Having few drinks or drinking in moderation once many a times doesnt cause any major issue , however response can be unpredictable too in some cases , so better to avoid it

The concurrent use of bupropion, an NDRI (norepinephrine-dopamine reuptake inhibitor), and alcohol is generally discouraged. Bupropion has been shown to lower the seizure threshold in some individuals, and the alcohol withdrawal phase—when the sedative effects of alcohol on the nervous system diminish—can lead to heightened neural excitation, increasing the risk of seizures. Abrupt cessation of alcohol while taking bupropion may further exacerbate this risk. Additionally, combining bupropion with alcohol can amplify side effects such as dizziness, drowsiness, and impaired concentration. Moreover, bupropion and alcohol have opposing mechanisms of action, which can negatively affect neurotransmitter balance, potentially worsening or triggering mood-related symptoms.in general the combination causes more harm than benefit.

Hi..you should not take bupropion and alcohol together. This is because alcohol can intensify the possible side effects associated with bupropion. It can also increase the risk of seizures, and the consequences can sometimes be fatal.