Is there a relation between asthma and an enlarged heart? I have found no evidence that definitely proves a link between the two. An argument that one could present is this: Asthma leads to labored breathing, which causes the heart to have to pump more often to get adequate amount of oxygen in the body. Does it make sense to therefore assume that since the heart is working harder than a normal person's heart (with no asthma), that the muscle becomes enlarged overtime?