Hello There. I can understand your concern, first of all, congratulations to the couple. as far as your question is concerned regarding Urinary Tract Infection, These drugs are safe during pregnancy and you don't need to worry much. is they were not safe, don't you think the gynec herself wouldn't have prescribed.? also, i feel your wife is not drinking enough water. if she was drinking enough water, the frequent urination would have caused the bacteria to wash away. ask her to take citrus fruits and lemonade also. and lots of water. best regards, Dr. Anil kumar jain