. Greetings. Dear Sir, I wish to enlighten you that itching and rashes could be due to many many reasons and may be tough for us to diagnose with the limited history you have provided. I would wish to request you to send images of the rashes your wife has. Most likely your wife has urticaria. This may need treatment with oral anti histamines to control the symptoms. You can apply calamine lotion for improvement of symptoms. Meet a qualified dermatologist for detailed evaluation and treatment. Further queries may be sent on follow up messaging. Hope this helps .