Creon can cause problems with gas and bloating, which in turn may have reduced your appetite. You can take Tab. PAN-D or Omeprazole 15-20 mins before food to relieve these symptoms you have. These drugs have no known interactions with Creon and can be safety taken. Drinking water is very good.
Health Tips
I’m sure you must already be following a healthy diet, considering your condition, in addition, try to avoid eating very close to bed time. Eat atleast 2 hours before you go to bed.