Hello, Partial or poor response to treatment in Recurrent Depressive Disorder will require a detailed assessment of various factors. These factors could be biological i.e. thyroid, anemia, uncontrolled diabetes, hypertension, history of stroke etc. These factors could be psychological like grief, bereavement, life stage related psychological complexes, etc. Social factors like percieved support, financial concerns, social pressure etc also will need a detailed assessment. Hence please discuss these issues with your psychiatrist further. Change/ augmentation of medication can be considered, an addition of psychological intervention can also be of great benefit to her treatment.. Hope this helps you. Best wishes for you and your mother..