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 What we need to understand about prednisone is that it is a drug that affects your DNA. Prednisone goes in and it goes inside your cells and it tells your cells to change the way they are sending messages to your body. That means that every single person who takes prednisone has their own unique experience with it. That means every single person has a different way that their body responds with their immune system.( Approximately take average 3-4 weeks but may take several months as steroid works in a different way )