Hi, The management of diabetic foot ulcers requires offloading the wound by using appropriate therapeutic footwear, daily saline or similar dressings to provide a moist wound environment, debridement when necessary, antibiotic therapy if osteomyelitis or cellulitis is present, optimal control of blood glucose, and evaluation and correction of peripheral arterial insufficiency. Wound coverage by cultured human cellsor heterogeneic dressings/grafts, application of recombinant growthfactors, and hyperbaric oxygen treatments also may be beneficial at times, but only if arterial insufficiency is not present.