Hello In most cases, minor eyelid twitch will disappear without you even noticing if you get enough rest and/or reduce or eliminate your intake of alcohol, tobacco, or caffeine. Blepharospasm does not occur while sleeping. If you have dry eyes causing irritation of the cornea or conjunctiva, treating it with over-the-counter artificial tears will often relieve minor eyelid twitch. The most commonly recommended treatment for benign essential blepharospasm is botulinum toxin (also known as Botox, Dysport, or Xeomin). It's approved for this use in both the U.S. and Canada. Botox is also commonly recommended for patients with hemifacial spasm. Dry Eye Syndrome Treatment When injected in very small quantities into the eye muscles, the drug may relieve spasms for several months. But the effect gradually wears off. Repeat injections are usually necessary. In mild cases of benign essential blepharospasm, doctors sometimes recommend medications such as: Clonazepam Lorazepam Trihexyphenidyl These usually provide only short-term relief and are rarely effective. Alternative treatments for benign essential blepharospasm include: Biofeedback Acupuncture Hypnosis Chiropractic Nutrition therapy Tinted glasses Consult ohthalmologist and physician for further evaluation and treatment.