Hi, yes you can take

Hi

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There is no significant clinically documented drug interaction between Naltrexone and Amitriptyline — they can generally be taken together safely. Amitriptyline works on serotonin/norepinephrine receptors while Naltrexone blocks opioid receptors; their mechanisms don't directly conflict. However, please inform your neurologist about Naltrexone at your next visit so they have the full picture and can monitor accordingly.