Hi Your wife seems to be having very dry skin and  welll as chapped skin over the hands. This could be due to excessive use of soap or detergents. also house hold chores like washing clothes or cooking can cause existing dryness to exacerbate and cause more itching. Please ask her to avoid working with water as much as possible. Use work gloves for house hold chores. Use a creamy hand lotion which is to re applied frequently as often as every couple of hours. If the hands do not show improvement then plan to see a dermatologist