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Lupus, also known as systemic lupus erythematosus, is a chronic autoimmune disease which can affect many body parts, including the joints, skin, kidneys, heart, lungs, blood vessels, or brain. When lupus occurs, the immune system of the body malfunctions, meaning, though it is responsible for fighting off viruses, bacteria, and germs and protecting the body, it suddenly starts to attack your body’s healthy tissues. In this disease, the immune system becomes overactive as opposed to the condition of HIV when it becomes underactive. This condition can range from mild to life-threatening.
The immune system in our bodies is responsible for producing antibodies that fight against antigens (intruders that sneak into our bodies to cause harm) and protect the body against any infections. Lupus occurs when the immune system of the body malfunctions and is unable to differentiate between antigens and healthy tissue. In this condition, the immune system in fact directs antibodies against the healthy tissue in our bodies, along with the antigens, causing swelling, pain, and tissue damage.
There are various types of lupus such as:
The chances of developing lupus are higher in people who:
The cause of lupus in most cases, is as yet unknown. A few potential triggers include:
The most common symptoms of lupus include:
Lupus can produce different and often confusing symptoms in the body, so it may take some time for a physician to diagnose it. In fact, this disease is known as 'the great imitator' as its symptoms mimic many other illnesses.
Usually, a general physician can diagnose lupus. Depending on the severity of your condition he may refer you to other specialists such as a dermatologist, cardiologist, nephrologist, neurologist, gastroenterologist, pulmonologist, or a perinatologist.
For diagnosing lupus your doctor will look for your current symptoms such as pain, heat, redness, swelling, and loss of function at a particular place in the body. He will also enquire about your complete medical history, and if you have a family history of lupus.
There is no single diagnostic test for systemic lupus, however, the test usually suggested by doctors for lupus is called the antinuclear antibody (ANA) test. This is not a test specifically for lupus, but this test along with many other laboratory tests can build up a picture providing more information to your doctor and finally confirm if it is lupus.
Other tests include:
Some major complications of lupus include:
Depending on the severity of your condition, your doctor may prescribe medicines to suppress the immune system, reduce inflammation, and treat pain, swelling and fever associated with lupus.
Research shows that lupus patients who exercise build stronger muscles, prevent joint stiffness, control fatigue, and avoid weight gain.
Before deciding on an exercise regimen, make sure to consult your doctor to find out what type of exercises suit you the best since some movements can be harmful if you have swollen joints or muscle pain.
Some exercises that you can consider are yoga, pilates, Tai Chi, dancing, swimming, and bicycling.
Constitutional (eg, fatigue, fever, arthralgia, weight changes)
Musculoskeletal (eg, arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis)
Dermatologic (eg, malar rash, photosensitivity, discoid lupus)
Renal (eg, acute or chronic renal failure, acute nephritic disease)
Neuropsychiatric (eg, seizure, psychosis)
Pulmonary (eg, pleurisy, pleural effusion, pneumonitis, pulmonary hypertension, interstitial lung disease)
Gastrointestinal (eg, nausea, dyspepsia, abdominal pain)
Cardiac (eg, pericarditis, myocarditis)
Hematologic (eg, cytopenias such as leukopenia, lymphopenia, anemia, or thrombocytopenia)
Roughly 3 out of every one lakh people in India suffer from lupus.
Lupus is very difficult to diagnose and treat, and is more often than not, diagnosed with great delay. It is a non-contagious chronic disease.
Lupus is five times more common in women than men. More than 90% of people with lupus are women between the ages of 15 and 45.
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