You may occasionally wake up with a swollen, puffy face. This could happen as a result of pressure being placed on your face while sleeping. However, a swollen, puffy face can also arise from a facial injury or indicate an underlying medical condition. There are multiple causes to name a few: - Allergic conjunctivitis - Preeclampsia - Cellulitis - Anaphylaxis - Drug allergy - Angioedema - Actinomycosis - Broken nose - External eyelid stye - Sinusitis I would advise you to visit the ER so that you can be examined and undergo the necessary investigations to rule out any underlying problems and have it treated accordingly.