What is male hypogonadism? What are the symptoms? Difference between estrogen dominance and hypogonadism? Am a male. My nipples are developed. Is this a sign of gynecomastia? I can't reduce fat around belly, abdominal weight gain and thigh fat. I do regular exercise. But, can't reduce fat on these areas. Crackling sound when raising legs.back pain & knee pain when doing exercise. ( back pain when doing any physical activity). Can DIM supplements reduce estrogen dominance?