Is there any other risk factor Isolated and one reading can be high in recent infection or inflammation If it was a one-time high reading, consider repeating it after a few weeks, as infections, injuries, or even recent exercise can transiently elevate hs-CRP. Chronic infections, autoimmune diseases, and metabolic syndrome can elevate hs-CRP. Conditions like insulin resistance, obesity, and fatty liver disease can contribute to systemic inflammation.