There have been studies (mainly done in animals) that suggest using Bupropion (the medicine in Bupron) slightly reduces the effectivity of Methylphenidate (the medicine in Inspiral). Anothet few articles suggest that in patients who are at a risk of seizures, using Bupropion if they are already on Methylphenidate may cause seizures. However, these are not studies that have been replicated rigorously. Some care must be taken with the use of these drugs. I would suggest discuss things with your Psychiatrist who had prescribed you the medicines. They may be able to explain things to you in more detail.