Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases. e.g., crescentic glomerulonephritis, microscopic polyarteritis and churg-strauss syndrome, bowel disease Crohn's Disease, ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis as well as with other autoimmune diseases drug-induced lupus, SLE, Felty's Syndrome. ANCA has classically been divided into C-ANCA and P-ANCA depending on the immunofluorescent pattern observed. More recently the specific antigens responsible for these patterns have been described and isolated. The antigen that gives the C-ANCA pattern is Proteinase-3 . Multiple antigens are responsible for P-ANCA pattern, the principle antigen being Myeloperoxidase (MPO). Patients with bowel disease have been shown to have antibodies that give a P-ANCA or C-ANCA pattern. These antibodies however may not be directed towards MPO. Patients with drug induced lupus, etc, often present with a P-ANCA pattern that is associated with antibodies against MPO.
No special preparation is needed for C-ANCA. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing C-ANCA. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||C ANCA detcted in positive cases|